Dissecting Daily and Circadian Expression Rhythms of Clock

The identification and investigation of novel clock-controlled genes CCGs has been conducted thus far mainly in model organisms such as nocturnal rodents, with limited information in humans, Here, we aimed to characterize daily and circadian expression rhythms of CCGs in human peripheral blood dur …

Circadian Rhythms

Scientists learn about circadian rhythms by studying humans and by using organisms with similar biological clock genes, such as fruit flies and mice, Researchers doing these experiments control the subject’s environment by altering light and dark periods, Then they look for changes in gene activity or other molecular signals, Scientists also study organisms with irregular circadian rhythms

The brain, circadian rhythms, and clock genes

The brain, circadian rhythms, and clock genes, Every day we experience profound changes in our mental and physical condition as body and brain alternate between states of high activity during the waking day and recuperation, rest, and repair during night time sleep, These cycles are not a passive response to the world around us: they are pre

Genetics of Circadian Rhythms

Circadian rhythms and sleep are inextricably linked, Sleep is a vital process linked to a myriad of processes including metabolism and synaptic plasticity 58, 59, PER mutations in both mouse and human show that the circadian clock directly regulates the timing of sleep onset ,

Mechanisms of rapid antidepressant effects of sleep

Mechanisms of rapid antidepressant effects of sleep deprivation therapy: clock genes and circadian rhythms Biol Psychiatry, 2013 Jun 15;7312:1164-71, doi: 10,1016/j,biopsych,2012,07,020, Epub 2012 Aug 18, Authors Blynn G Bunney 1 , William E Bunney, Affiliation 1 Department of Psychiatry

Circadian Rhythms: Genes at the Core of Our Internal

Circadian rhythms are the natural biological rhythms that shape our biology, Most people know about the master clock in our brain that keeps us on a wake-sleep cycle over 24 hours, This is driven by our master ‘clock’ genes, It turns out that we also have circadian cycles peripheral clocks in most organs such as the liver, pancreas, and

Genetics of Circadian Rhythms

In mammals, genetic influences of circadian rhythms occur at many levels, A set of core “clock genes” have been identified that form a feedback loop of gene transcription and translation, The core genetic clockwork generates circadian rhythms in cells throughout the body, Polymorphisms in both core …

Circadian rhythms and memory: not so simple as cogs and

As neuronal plasticity is the translation of numerous inputs, illuminating the direct molecular links between circadian rhythms and memory consolidation remains a daunting task, However, the elucidation of how clock genes contribute to synaptic plasticity could provide such a link, Furthermore, the idea that memory training could actually function as a zeitgeber for hippocampal neurons is

Circadian Organization of the Mammalian Retina: From Gene

Whereas, daytime circadian and light drive on dopamine secretion serves to reinforce the rise in the expression of Period clock genes during the day portion of the molecular circadian cycle, night-time GABA-mediated stimulation of PERIOD protein degradation may reinforce the falling phase of the clock gene cycle that occurs at night, removing these negative feedback complexes and preparing

The Circadian Clock in Oral Health and Diseases

Clock genes show circadian rhythms in salivary glands, J Dent Res 91:783-788, [PMC free article] [Google Scholar] Zheng L, Seon YJ, Mourao MA, Schnell S, Kim D, Harada H, et al, 2013, Circadian rhythms regulate amelogenesis, Bone 55:158-165, [PMC free article] [Google Scholar] Zhu Y, Stevens RG, Hoffman AE, Tjonneland A, Vogel UB, Zheng T, et al, 2011, Epigenetic impact of long-term

Sleep homeostasis and the circadian clock: Do the

Individual SCN neurons show a circadian rhythm but these rhythms show a large variability in period length Welsh et al,, 1995, Inside each neuron, the rhythm is generated and maintained with a transcription-translational feedback loop that is regulated by 5–7 core clock genes Albrecht, 2002,

Clock genes show circadian rhythms in salivary glands,

Circadian rhythms are endogenous self-sustained oscillations with 24-hour periods that regulate diverse physiological and metabolic processes through complex gene regulation by “clock” transcription factors, The oral cavity is bathed by saliva, and its amount and content are modified within regular daily intervals, The clock mechanisms that control salivary production remain unclear, Our