The Pro-Inflammatory Chemokines CXCL9, CXCL10 and CXCL11

The induction of CXCL9, CXCL10, and CXCL11 gene expression in response to SARS-CoV-2 infection was markedly reduced by treatment with the AKT inhibitor GSK690693, Samples from COVID-19 positive individuals also displayed marked increases in CXCL9, CXCL10, and CXCL11 transcripts as well as transcripts in the AKT pathway, The current study elucidates potential pathway specific targets for

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune response, This axis works primarily for immune cell migration, differentiation, and activation, Immune reactivity for each disorder is dependent on the types of leukocytes infiltrating the focal sites, Therefore, it is critical to understand which immune cells are involved in migration, differentiation, and activation through this axis, The axis also

CXCL9, CXCL10, CXCL11, and their receptor CXCR3 in

CXCL9, CXCL10, and CXCL11 lack glutamic acid-leucine-arginine ELR, and are unique, because they are more closely related to each other than to any other chemokine, The aforementioned chemokines are especially involved in Th1-type response and in various diseases, as their expression correlates with the tissue infiltration of T cells, Their production is strongly induced by interferon gamma

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation

Thus, a better understanding of CXCL9, -10, -11/CXCR3 axis is necessary to develop effective cancer control, In this article, we summarize recent evidence regarding CXCL9, CXCL10, CXCL11/CXCR3 axis in the immune system and discuss their potential role in cancer treatment,

CXCL9, CXCL10, CXCL11, and CXCR3 in Dry Eye Syndrome

The aim of this study is to investigate the expression of CXCL9, CXCL10, CXCL11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome, Thirty-three patients with dry eye 16 Sjögren’s syndrome and 17 non-Sjögren’s syndrome patients and 15 control subjects were recruited, The concentrations of CXCL9, CXCL10, and CXCL11 in tears were measured using …

CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation – A

CXCL9, CXCL10, CXCL11/ CXCR3 axis for immune response, This axis works primarily for immune cell migration, differentiation, and activation, Immune reactivity for each disorder is dependent on the types of leukocytes infiltrating the focal sites, Therefore, it is critical to understand which immune cells are involved in migration, differentiation, and activation through this axis, The axis

Adipose tissue gene expression of CXCL10 and CXCL11

Expression of CXCL9, CXCL10, and CXCL11 correlated significantly with various pro-inflammatory markers, including family members of interleukins, chemokines, and their prospective receptors r ⩾ 0,339, p ⩽ 0,009, but not anti-inflammatory markers, CXCL11 expression correlated specifically with the expression of CCL5, CCL18, TLR3, TLR4, TLR8, IRF5, and NF-κB r ⩾ 0,279, p ⩽ 0,039

Frontiers

General Introduction to The Chemokine Network

CXCL11 – an overview

CXCL9, CXCL10, and CXCL11 also known as Mig, IP-10, and I-TAC, respectively form a structurally and functionally related subgroup of non-ELR CXC chemokines that regulate the migration of Th1-polarized effector T cells to inflamed sites during the adaptive immune response, Two key properties common to all three of these chemokines account for their involvement in Th1 responses, First, all

Interleukin-27 and IFNγ regulate the expression of CXCL9

In summary, IL-27 up-regulated the CXCL9, CXCL10, and CXCL11 chemokine expression in hepatic cells, IL-27 regulated CXCR3 ligand expression in IFNγ-dependent manner during acute hepatitis suggesting a complementary role of IL-27 and IFNγ to moderate liver inflammation via regulation of CXCR3 ligands, Key message: IL-27 up-regulated CXCR3 ligand expression in human hepatic cells …

CXCL11

Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α, This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, CXCL9 and CXCL10, CXCL11 is chemotactic for activated T cells,

Frontiers

Chemokines and their receptors play an important role in the recruitment, activation and differentiation of immune cells, The chemokine receptor, CXCR3, and its ligands, CXCL9, CXCL10, and CXCL11 are key immune chemoattractants during interferon-induced inflammatory responses, Inflammation of the skin resulting from infections or autoimmune disease drives expression of CXCL9/10/11 and the

CXCL10 C-X-C motif chemokine ligand 10 [ human]

The combination of CXCL9, CXCL10 and CXCL11 levels during primary HIV infection predicts HIV disease progression, Inflammatory Activation of Astrocytes Facilitates Melanoma Brain Tropism via the CXCL10-CXCR3 Signaling Axis, CXCL10 an important chemokine associated with cytokine storm in COVID-19 infected patients, The authors found that the transcriptionally independent suppression of …

CXCL10 Gene – GeneCards

ART3 CXCL10 CXCL9 NAAA CXCL11 NUP54 SDAD1 SDAD1-AS1 KR153194-146 piR-58297-350: GH04J076042: Enhancer: 0,6: FANTOM5 Ensembl: 58-18,8-18762: 0,5: ZBTB33 ATF2 JUNB FOS: CXCL11 lnc-FAM47E-1 piR-33422-320 piR-39099-185 piR-58297-349 CXCL9 ART3 CXCL10 NAAA HSALNG0035292 – Elite GeneHancer and/or Elite GeneHancer-gene association Download …