FHL1 is a major host factor for chikungunya virus infection

Chikungunya virus CHIKV is a re-emerging alphavirus that is transmitted to humans by mosquito bites and causes musculoskeletal and joint pain 1,2,Despite intensive investigations, the human cellular factors that are critical for CHIKV infection remain unknown, hampering the understanding of viral pathogenesis and the development of anti-CHIKV therapies,

FHL1 is a major host factor for chikungunya virus

FHL1 is a key factor expressed by humans and mice that is required for chikungunya virus infection and is therefore a promising target for the development of therapies against chikungunya virus,

FHL1 is a major host factor for chikungunya virus

Here we identified the four-and-a-half LIM domain protein 1 FHL13 as a host factor that is required for CHIKV permissiveness and pathogenesis in humans and mice, Ablation of FHL1 expression results in the inhibition of infection by several CHIKV strains and o’nyong-nyong virus, but not by other alphaviruses and flaviviruses,

FHL1 is a major host factor for chikungunya virus

FHL1 is a major host factor for chikungunya virus infection, Laurent Meertens INSERM U944, CNRS UMR 7212, Genomes & Cell Biology of Disease Unit, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, Paris, France,

FHL1 is a key player of chikungunya virus tropism and

Chikungunya is an infectious disease caused by the chikungunya virus CHIKV, an alphavirus transmitted to humans by Aedes mosquitoes, and for which there is no licensed vaccine nor antiviral treatments, By using a loss-of-function genetic screen, we have recently identified the FHL1 protein as an essential host factor for CHIKV tropism and pathogenesis, FHL1 is highly expressed in muscles

Four and a half LIM domains protein 1 can be as a double

Recently, FHL1 was identified as a major host factor for chikungunya virus CHIKV infection in both humans and mice, Based on more recent findings over the last decade, FHL1 is proposed to play a dual role in cancer progression, On the one hand, FHL1 expression is suppressed in several cancer types, which correlates with increased metastatic disease and decreased survival, Moreover, FHL1 is

A New Host Factor Essential for Chikungunya Virus

FHL1 has been identified as a host protein that is essential for chikungunya virus CHIKV replication, FHL1 interacts with the chikungunya non-structural protein 3, which is thought to recruit cellular proteins to the viral replication complex, Inhibition of this interaction is a …

FHL1 is a key player of chikungunya virus tropism and

Chikungunya is an infectious disease caused by the chikungunya virus CHIKV, an alphavirus transmitted to humans by Aedes mosquitoes, and for which there is no licensed vaccine nor antiviral treatments, By using a loss-of-function genetic screen, we have recently identified the FHL1 protein as an essential host factor for CHIKV tropism and pathogenesis,

A protein essential for chikungunya virus replication

Elucidating the molecular structure of the FHL1-nsP3 complex could represent a major step forward in the development of FHL1 is a major host factor for …

Structural and Functional Characterization of Host FHL1

Decades of insufficient control have resulted in unprecedented spread of chikungunya virus CHIKV around the globe, and millions have suffered from the highly debilitating disease, Nevertheless, the current understanding of CHIKV-host interactions and adaptability of the virus to replication in mos … Structural and Functional Characterization of Host FHL1 Protein Interaction with

A protein essential for chikungunya virus replication

Chikungunya is an infectious disease caused by a mosquito-borne virus transmitted to humans, It is characterized by high fever and intense joint …

Une protéine essentielle à la réplication du virus

FHL1 is a major host factor for chikungunya virus infection,Laurent Meertens, Mohamed Lamine Hafirassou, Therese Couderc, Lucie Bonnet-Madin, Vasiliya Kril, Beate M, Kümmerer, Athena Labeau, Alexis Brugier, Etienne Simon-Loriere, Julien Burlaud-Gaillard, Cécile Doyen, Laura Pezzi, Thibaud Goupil, Sophia Rafasse, Pierre-Olivier Vidalain, Anne Bertrand Legout, Lucie …

Nature,重大进展！鉴定出FHL1是基孔肯雅病毒感染的主要宿主因 …

相关研究结果近期发表在Nature期刊上，论文标题为“FHL1 is a major host factor for chikungunya virus infection”。 剔除FHL1表达可抑制几种CHIKV毒株和奥-奈氏病毒