Les causes du diabète

Les groupes HLA–DR3 ou DR4 sont trouvés chez 90% des personnes ayant un diabète de type 1, comparé à environ 50 % dans l’ensemble de la population, Les personnes ayant un groupe HLA–DR3 ou DR4 ont un risque plus grand d’avoir un jour un diabète même si la majorité d’entre elles ne le développera pas, Un tiers des personnes ayant un diabète de type 1 ont l’association HLA

HLA-DR3 and DR4 and their relation to the incidence and

Patients with either HLA–DR3 or DR4 were less likely to progress to proliferative retinopathy compared with those who were negative for both, although these relations were not statistically significant, The associations did not vary after adjusting for hypertension status, baseline retinopathy, and glycosylated hemoglobin levels, or after stratifying by duration of diabetes less than 10 years

What is dr3 and dr4?

DR3 is a component gene-allele of the AH8, 1 haplotype in Northern and Western Europeans, Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease, Type 1 diabetes mellitus is strongly associated with HLA–DR3 or HLA–DR4,

HLA-DR3

Overview

The HLA association of insulin-dependent type I diabetes

The class II gene products, HLA–DR3 and DR4, may be the primary susceptibility genes for IDDM, They mediate the pathogenetical immune mechanisms which, under the additional influence of special MHC-genes of class I and III, lead to diabetes, The extremely high frequency of HLA-DR3, DR4 heterozygotes among diabetic patients and the genetic heterogeneity in B8, DR3 positive patients on the one

HLA-DR4

Overview

WikiGenes

Disease Relevance of HLA-DRB4

HLA-DRB4 major histocompatibility complex, class II, DR

HLA-DR14/DR7/DQ5 alleles significantly increase the risk for toxic shock syndrome, regardless of individual variations in T cell receptor variable region repertoires, IA2 positivity was associated with HLA–DR4/X and HLA–DR3/4 positivity, and hypothyroidism was linked to HLA–DR4/4, More females carried the HLA–DR4/4 genotype or were thyroid

Association of Chronic Lyme Arthritis with HLA-DR4 and HLA

Five had HLA–DR4 and HLA–DR3, four had HLA–DR4 and HLA-DR2, three had HLA–DR4 and HLA-DR1, and the remaining four had HLA–DR4 in association with a different DR specificity, A secondary

Association of MHC and rheumatoid arthritis: HLA-DR4 and

Introduction, More than 20 years ago, Stastny [] reported that HLA–DR4 is associated with RA,Nine years later, Gregersen et al [] proposed the shared epitope SE hypothesis based on the observation that the RA-associated DRB1 alleles encode a common sequence of amino acids corresponding to residues 67-74,Several SE-positive SE+ DRB1 alleles have since been reported to …

Conserved extended haplotypes discriminate HLA-DR3

Graphical description of extended HLA–DR3 haplotypes from T1D patients, Each column corresponds to a chromosome and represents the 4,91 Mbp region covered by the 2360 SNPs analyzed,

Two SNPs in the MHC Identify the High-Risk HLA-DR3/4,DQB1

Excluding individuals with the rs2040410 G/G genotype excluded all subjects with DR4/4 N=11, DR4/X N=76 and DRX/X N=40, where X was neither DR3 nor DR4, Among the remaining 92 subjects, excluding individuals with the rs7454108 T/T genotype excluded those with DR3/3 N=9, DR3/X N=57, and DR3/4,non-DQB1*0302 N=7, Subjects with the DR3/4,DQB1*0302 genotype were the only …

HLA : typage [Typage HLA]

Le système HLA est un ensemble de gènes qui s’expriment sous la forme d’antigènes à la surface de la plupart des cellules de l’organisme et qui permettent à chaque individu de reconnaître ses propres cellules ou, en d’autres termes, de différencier “ le soi ” du “ non-soi ”, Le typage ou phénotypage HLA consiste à identifier ces antigènes, caractéristiques de l’individu

HLA-DR patterns in pernicious anaemia,

The pattern of HLA-DR antigens was studied in a group of 66 patients with Addisonian pernicious anaemia, comprising a subgroup of 18 patients with associated endocrine disease and a subgroup of 48 patients with no associated endocrine disease, Compared with a control group of 120 subjects all 66 patients showed an increase in HLA-DR2 and DR4 and a decrease in DR3 p less than …

HLA-DR4 in insulin-dependent andtheir A clue to

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for only DR3 or DR4 was considered to be homozygous, whichmaynotbethecase, butwhichactuallyoverestimates slightly the frequencies of DR3 and DR4 in the diabetic population, making the comparisons with the family data moreconservative, Thegenefrequencies, accordingly,were as follows: DR3, 57/194 = 0,29; DR4, 83/194 = 0,43; DRx, 54/194 = 0,28